Assay Detail
Toxicity
CHEMBL5049165
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant MAO-A expressed in supersomes assessed as inhibition of 4-hydroxyquinoline formation using kynuramine as substrate by spectrofluorimetric analysis
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Toxicity |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Probing Fluorinated Motifs onto Dual AChE-MAO B Inhibitors: Rational Design, Synthesis, Biological Evaluation, and Early-ADME Studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.37 | 5.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5085674 | — | — | 1 | 5.85 |
| CHEMBL5083014 | — | — | 1 | 5.70 |
| CHEMBL4598256 | — | — | 1 | 5.62 |
| CHEMBL5090504 | — | — | 1 | 5.60 |
| CHEMBL4571763 | — | — | 1 | 5.55 |
| CHEMBL5083737 | — | — | 1 | 5.38 |
| CHEMBL5081663 | — | — | 1 | 5.11 |
| CHEMBL5094348 | — | — | 1 | 5.09 |
| CHEMBL5072382 | — | — | 1 | 4.96 |
| CHEMBL3586771 | — | — | 1 | 4.82 |
| CHEMBL502 | DONEPEZIL | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5085674 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL5083014 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL4598256 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL5090504 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL4571763 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL5083737 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL5081663 | — | IC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL5094348 | — | IC50 | = | 8100.0 | nM | 5.09 |
| CHEMBL5072382 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL3586771 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL502 | DONEPEZIL | IC50 | - | — | - |