Assay Detail
Binding
CHEMBL5049166
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Inhibition of human recombinant MAO-B expressed in supersomes assessed as inhibition of 4-hydroxyquinoline formation using kynuramine as substrate by spectrofluorimetric analysis
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Probing Fluorinated Motifs onto Dual AChE-MAO B Inhibitors: Rational Design, Synthesis, Biological Evaluation, and Early-ADME Studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 6.99 | 8.09 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5082824 | — | — | 1 | 8.09 |
| CHEMBL5090153 | — | — | 1 | 8.00 |
| CHEMBL3586771 | — | — | 1 | 8.00 |
| CHEMBL5083014 | — | — | 1 | 7.92 |
| CHEMBL396778 | SAFINAMIDE | 4.0 | 1 | 7.75 |
| CHEMBL4571763 | — | — | 1 | 7.52 |
| CHEMBL5081663 | — | — | 1 | 7.14 |
| CHEMBL4598256 | — | — | 1 | 6.96 |
| CHEMBL5085674 | — | — | 1 | 6.89 |
| CHEMBL5083613 | — | — | 1 | 6.89 |
| CHEMBL5090504 | — | — | 1 | 6.85 |
| CHEMBL5078658 | — | — | 1 | 6.80 |
| CHEMBL5072382 | — | — | 1 | 6.58 |
| CHEMBL5094348 | — | — | 1 | 6.46 |
| CHEMBL5079544 | — | — | 1 | 6.38 |
| CHEMBL4464759 | — | — | 1 | 6.32 |
| CHEMBL5081574 | — | — | 1 | 6.28 |
| CHEMBL5083737 | — | — | 1 | 6.25 |
| CHEMBL4453856 | — | — | 1 | 5.82 |
| CHEMBL502 | DONEPEZIL | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5082824 | — | IC50 | = | 8.2 | nM | 8.09 |
| CHEMBL5090153 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL3586771 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL5083014 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL396778 | SAFINAMIDE | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL4571763 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL5081663 | — | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL4598256 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL5085674 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL5083613 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL5090504 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL5078658 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL5072382 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL5094348 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL5079544 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL4464759 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL5081574 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL5083737 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL4453856 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL502 | DONEPEZIL | IC50 | - | — | - |