Assay Detail
Binding
CHEMBL5049313
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H](S)-2-(tert-butoxy)-2-(2-methyl-4-(p-tolyl)quinolin-3-yl)acetic acid from LEDGF-binding site of recombinant T124/T125 polymorphic HIV1 integrase by LIDIA assay
33
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Design, Synthesis, and Preclinical Profiling of GSK3739936 (BMS-986180), an Allosteric Inhibitor of HIV-1 Integrase with Broad-Spectrum Activity toward 124/125 Polymorphs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 33 | 7.60 | 8.31 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5089130 | — | — | 2 | 8.31 |
| CHEMBL5084138 | — | — | 1 | 8.17 |
| CHEMBL5091879 | — | — | 1 | 8.03 |
| CHEMBL5093378 | — | — | 1 | 7.96 |
| CHEMBL5078859 | — | — | 1 | 7.94 |
| CHEMBL5077625 | — | — | 1 | 7.94 |
| CHEMBL5089101 | — | — | 1 | 7.93 |
| CHEMBL5074148 | — | — | 1 | 7.90 |
| CHEMBL5076276 | — | — | 1 | 7.88 |
| CHEMBL5077187 | — | — | 1 | 7.88 |
| CHEMBL5070004 | — | — | 1 | 7.87 |
| CHEMBL5093292 | — | — | 1 | 7.83 |
| CHEMBL5077638 | — | — | 1 | 7.81 |
| CHEMBL5084420 | — | — | 1 | 7.80 |
| CHEMBL5087287 | — | — | 1 | 7.78 |
| CHEMBL5079235 | — | — | 2 | 7.75 |
| CHEMBL5077943 | — | — | 1 | 7.75 |
| CHEMBL5088057 | — | — | 1 | 7.74 |
| CHEMBL5094894 | — | — | 1 | 7.71 |
| CHEMBL5087777 | — | — | 1 | 7.68 |
| CHEMBL5080580 | — | — | 1 | 7.52 |
| CHEMBL5092389 | — | — | 1 | 7.52 |
| CHEMBL5090529 | — | — | 1 | 7.51 |
| CHEMBL5087827 | — | — | 1 | 7.49 |
| CHEMBL5085847 | — | — | 1 | 7.45 |
| CHEMBL5087982 | — | — | 1 | 7.31 |
| CHEMBL5080240 | — | — | 1 | 7.27 |
| CHEMBL5080247 | — | — | 1 | 7.26 |
| CHEMBL5092167 | — | — | 1 | 7.13 |
| CHEMBL5080087 | — | — | 1 | 7.01 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5089130 | — | IC50 | = | 4.9 | nM | 8.31 |
| CHEMBL5084138 | — | IC50 | = | 6.7 | nM | 8.17 |
| CHEMBL5089130 | — | IC50 | = | 7.9 | nM | 8.10 |
| CHEMBL5091879 | — | IC50 | = | 9.4 | nM | 8.03 |
| CHEMBL5093378 | — | IC50 | = | 11.1 | nM | 7.96 |
| CHEMBL5078859 | — | IC50 | = | 11.4 | nM | 7.94 |
| CHEMBL5077625 | — | IC50 | = | 11.6 | nM | 7.94 |
| CHEMBL5089101 | — | IC50 | = | 11.7 | nM | 7.93 |
| CHEMBL5074148 | — | IC50 | = | 12.7 | nM | 7.90 |
| CHEMBL5076276 | — | IC50 | = | 13.2 | nM | 7.88 |
| CHEMBL5077187 | — | IC50 | = | 13.3 | nM | 7.88 |
| CHEMBL5070004 | — | IC50 | = | 13.4 | nM | 7.87 |
| CHEMBL5093292 | — | IC50 | = | 14.7 | nM | 7.83 |
| CHEMBL5077638 | — | IC50 | = | 15.5 | nM | 7.81 |
| CHEMBL5084420 | — | IC50 | = | 15.9 | nM | 7.80 |
| CHEMBL5087287 | — | IC50 | = | 16.7 | nM | 7.78 |
| CHEMBL5077943 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL5079235 | — | IC50 | = | 17.7 | nM | 7.75 |
| CHEMBL5088057 | — | IC50 | = | 18.1 | nM | 7.74 |
| CHEMBL5094894 | — | IC50 | = | 19.3 | nM | 7.71 |
| CHEMBL5087777 | — | IC50 | = | 21.1 | nM | 7.68 |
| CHEMBL5080580 | — | IC50 | = | 30.4 | nM | 7.52 |
| CHEMBL5092389 | — | IC50 | = | 30.2 | nM | 7.52 |
| CHEMBL5090529 | — | IC50 | = | 30.7 | nM | 7.51 |
| CHEMBL5087827 | — | IC50 | = | 32.6 | nM | 7.49 |
| CHEMBL5085847 | — | IC50 | = | 35.5 | nM | 7.45 |
| CHEMBL5079235 | — | IC50 | = | 35.5 | nM | 7.45 |
| CHEMBL5087982 | — | IC50 | = | 49.2 | nM | 7.31 |
| CHEMBL5080240 | — | IC50 | = | 53.5 | nM | 7.27 |
| CHEMBL5080247 | — | IC50 | = | 55.5 | nM | 7.26 |
| CHEMBL5092167 | — | IC50 | = | 73.3 | nM | 7.13 |
| CHEMBL5080087 | — | IC50 | = | 98.0 | nM | 7.01 |
| CHEMBL5081928 | — | IC50 | = | 100000.0 | nM | 4.00 |