Assay Detail
Binding
CHEMBL5049858
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of full length SARS-CoV-2 3CL protease using Dabcyl-KTSAVLQ-SGFRKME-Edans fluorogenic peptide as substrate by FRET assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Novel Nitrile Peptidomimetics for Treating COVID-19.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 8.19 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5088846 | — | — | 1 | 9.00 |
| CHEMBL4802135 | NIRMATRELVIR | 4.0 | 1 | 8.52 |
| CHEMBL5090635 | — | — | 1 | 8.40 |
| CHEMBL5084811 | — | — | 1 | 8.30 |
| CHEMBL5094771 | — | — | 1 | 8.22 |
| CHEMBL5082806 | — | — | 1 | 8.15 |
| CHEMBL5090310 | — | — | 1 | 7.96 |
| CHEMBL5086948 | — | — | 1 | 7.89 |
| CHEMBL5071828 | — | — | 1 | 7.82 |
| CHEMBL5077894 | — | — | 1 | 7.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5088846 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL4802135 | NIRMATRELVIR | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL5090635 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL5084811 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL5094771 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL5082806 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL5090310 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL5086948 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL5071828 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL5077894 | — | Ki | = | 21.0 | nM | 7.68 |