Assay Detail
Binding
CHEMBL5050108
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to CRBN (unknown origin) measured by Fluorescent Polarization assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Development of Potent and Selective Janus Kinase 2/3 Directing PG-PROTACs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 8.36 | 10.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5090416 | — | — | 1 | 10.70 |
| CHEMBL4744617 | — | — | 1 | 9.51 |
| CHEMBL5078429 | — | — | 1 | 9.35 |
| CHEMBL5082689 | — | — | 1 | 8.95 |
| CHEMBL4742130 | — | — | 1 | 8.81 |
| CHEMBL5090604 | — | — | 1 | 8.42 |
| CHEMBL5074539 | — | — | 1 | 7.82 |
| CHEMBL5073737 | — | — | 1 | 7.72 |
| CHEMBL5082136 | — | — | 1 | 7.71 |
| CHEMBL5092577 | — | — | 1 | 7.70 |
| CHEMBL5077200 | — | — | 1 | 7.62 |
| CHEMBL5094176 | — | — | 1 | 5.98 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5090416 | — | IC50 | = | 0.02 | nM | 10.70 |
| CHEMBL4744617 | — | IC50 | = | 0.31 | nM | 9.51 |
| CHEMBL5078429 | — | IC50 | = | 0.45 | nM | 9.35 |
| CHEMBL5082689 | — | IC50 | = | 1.13 | nM | 8.95 |
| CHEMBL4742130 | — | IC50 | = | 1.55 | nM | 8.81 |
| CHEMBL5090604 | — | IC50 | = | 3.81 | nM | 8.42 |
| CHEMBL5074539 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL5073737 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL5082136 | — | IC50 | = | 19.6 | nM | 7.71 |
| CHEMBL5092577 | — | IC50 | = | 20.2 | nM | 7.70 |
| CHEMBL5077200 | — | IC50 | = | 23.9 | nM | 7.62 |
| CHEMBL5094176 | — | IC50 | = | 1045.0 | nM | 5.98 |