Assay Detail
Binding
CHEMBL5050145
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Inhibition of rat electron transport chain complex 1 assessed as reduction in cellular ATP measured after 24 hrs by celltiter-glo assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Identification of the Highly Active, Species Cross-Reactive Complex I Inhibitor BAY-179.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.62 | 7.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5086239 | — | — | 1 | 7.66 |
| CHEMBL4798829 | — | — | 1 | 7.57 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5086239 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL4798829 | — | IC50 | = | 27.0 | nM | 7.57 |