Assay Detail
Functional
CHEMBL5050277
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Antitrypanosomal activity against bloodstream Trypanosoma congolense IL3000 assessed as parasite growth inhibition incubated for 69 hrs by resazurin dye based fluorescence analysis
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma congolense |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Repositioning of a Diaminothiazole Series Confirmed to Target the Cyclin-Dependent Kinase CRK12 for Use in the Treatment of African Animal Trypanosomiasis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 8.53 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5088920 | — | — | 1 | 9.40 |
| CHEMBL5076865 | — | — | 1 | 9.23 |
| CHEMBL5094897 | — | — | 1 | 8.89 |
| CHEMBL5084963 | — | — | 1 | 8.60 |
| CHEMBL5074906 | — | — | 1 | 8.49 |
| CHEMBL5084432 | — | — | 1 | 8.08 |
| CHEMBL5072657 | — | — | 1 | 7.80 |
| CHEMBL5089071 | — | — | 1 | 7.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5088920 | — | EC50 | = | 0.4 | nM | 9.40 |
| CHEMBL5076865 | — | EC50 | = | 0.59 | nM | 9.23 |
| CHEMBL5094897 | — | EC50 | = | 1.3 | nM | 8.89 |
| CHEMBL5084963 | — | EC50 | = | 2.5 | nM | 8.60 |
| CHEMBL5074906 | — | EC50 | = | 3.2 | nM | 8.49 |
| CHEMBL5084432 | — | EC50 | = | 8.3 | nM | 8.08 |
| CHEMBL5072657 | — | EC50 | = | 16.0 | nM | 7.80 |
| CHEMBL5089071 | — | EC50 | = | 18.0 | nM | 7.75 |