Assay Detail
Binding
CHEMBL5050325
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Inhibition of BRD3-BD2 (unknown origin) assessed as dissociation constant by TR-FRET method
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
CRCM5484: A BET-BDII Selective Compound with Differential Anti-leukemic Drug Modulation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.08 | 7.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4635134 | GSK620 | — | 1 | 7.14 |
| CHEMBL4636881 | GSK046 | — | 1 | 7.01 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4635134 | GSK620 | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL4636881 | GSK046 | IC50 | = | 98.0 | nM | 7.01 |