Assay Detail
Binding
CHEMBL5050784
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Inhibition of PLD1 (unknown origin) expressed in human HEK cells by immunoprecipitation assay
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of Phospholipase D Inhibitors with Improved Drug-like Properties and Central Nervous System Penetrance.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 6.82 | 7.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5085284 | — | — | 1 | 7.66 |
| CHEMBL5078848 | — | — | 1 | 7.48 |
| CHEMBL5092677 | — | — | 1 | 7.40 |
| CHEMBL5078394 | — | — | 1 | 7.37 |
| CHEMBL5085809 | — | — | 1 | 7.36 |
| CHEMBL4446255 | — | — | 1 | 7.31 |
| CHEMBL5092708 | — | — | 1 | 7.18 |
| CHEMBL5088048 | — | — | 1 | 7.17 |
| CHEMBL5083605 | — | — | 1 | 7.15 |
| CHEMBL5086717 | — | — | 1 | 7.12 |
| CHEMBL5074314 | — | — | 1 | 7.00 |
| CHEMBL5092706 | — | — | 1 | 6.96 |
| CHEMBL5075520 | — | — | 1 | 6.92 |
| CHEMBL5076666 | — | — | 1 | 6.89 |
| CHEMBL5080858 | — | — | 1 | 6.85 |
| CHEMBL5086297 | — | — | 1 | 6.77 |
| CHEMBL5080277 | — | — | 1 | 6.70 |
| CHEMBL5080618 | — | — | 1 | 6.55 |
| CHEMBL5080871 | — | — | 1 | 6.50 |
| CHEMBL5081973 | — | — | 1 | 6.44 |
| CHEMBL5093394 | — | — | 1 | 6.42 |
| CHEMBL5090919 | — | — | 1 | 6.31 |
| CHEMBL5085765 | — | — | 1 | 6.01 |
| CHEMBL5094742 | — | — | 1 | 5.92 |
| CHEMBL5092637 | — | — | 1 | 5.03 |
| CHEMBL5083676 | — | — | 1 | - |
| CHEMBL5087594 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5085284 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL5078848 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL5092677 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL5078394 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL5085809 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL4446255 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL5092708 | — | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL5088048 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL5083605 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL5086717 | — | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL5074314 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL5092706 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL5075520 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL5076666 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL5080858 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL5086297 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL5080277 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL5080618 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL5080871 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL5081973 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL5093394 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL5090919 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL5085765 | — | IC50 | = | 970.0 | nM | 6.01 |
| CHEMBL5094742 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL5092637 | — | IC50 | = | 9300.0 | nM | 5.03 |
| CHEMBL5083676 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5087594 | — | IC50 | > | 10000.0 | nM | - |