Assay Detail
Functional
CHEMBL5050786
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Antiproliferative activity against human Calu-1 cells assessed as reduction on cell viability by cellular assay
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Calu-1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of Phospholipase D Inhibitors with Improved Drug-like Properties and Central Nervous System Penetrance.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 6.97 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5085284 | — | — | 1 | 8.70 |
| CHEMBL5085809 | — | — | 1 | 8.22 |
| CHEMBL5074314 | — | — | 1 | 8.22 |
| CHEMBL4446255 | — | — | 1 | 8.00 |
| CHEMBL5078848 | — | — | 1 | 7.80 |
| CHEMBL5092677 | — | — | 1 | 7.50 |
| CHEMBL5088048 | — | — | 1 | 7.36 |
| CHEMBL5080277 | — | — | 1 | 7.27 |
| CHEMBL5078394 | — | — | 1 | 7.24 |
| CHEMBL5092708 | — | — | 1 | 7.13 |
| CHEMBL5083605 | — | — | 1 | 7.11 |
| CHEMBL5092706 | — | — | 1 | 7.11 |
| CHEMBL5086717 | — | — | 1 | 6.80 |
| CHEMBL5076666 | — | — | 1 | 6.75 |
| CHEMBL5080858 | — | — | 1 | 6.75 |
| CHEMBL5080871 | — | — | 1 | 6.72 |
| CHEMBL5081973 | — | — | 1 | 6.55 |
| CHEMBL5090919 | — | — | 1 | 6.34 |
| CHEMBL5093394 | — | — | 1 | 6.25 |
| CHEMBL5080618 | — | — | 1 | 6.14 |
| CHEMBL5075520 | — | — | 1 | 6.01 |
| CHEMBL5094742 | — | — | 1 | 5.96 |
| CHEMBL5086297 | — | — | 1 | 5.92 |
| CHEMBL5085765 | — | — | 1 | 5.38 |
| CHEMBL5083676 | — | — | 1 | - |
| CHEMBL5087594 | — | — | 1 | - |
| CHEMBL5092637 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5085284 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL5085809 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL5074314 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL4446255 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL5078848 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL5092677 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL5088048 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL5080277 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL5078394 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL5092708 | — | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL5083605 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL5092706 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL5086717 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL5076666 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL5080858 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL5080871 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL5081973 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL5090919 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL5093394 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL5080618 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL5075520 | — | IC50 | = | 980.0 | nM | 6.01 |
| CHEMBL5094742 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL5086297 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL5085765 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL5083676 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5087594 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5092637 | — | IC50 | > | 10000.0 | nM | - |