Assay Detail
Binding
CHEMBL5053384
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant rat/human ADAMTS7 hybrid using HiLyteFluor-488 DELSSMVLELRGLRT-K(QXL520)-E-NH2 as substrate incubated for 120 mins and measured by FRET assay
160
Total Activities
122
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Substituted hydantoinamides as adamts7 antagonists
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 160 | 7.27 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5075231 | — | — | 2 | 8.70 |
| CHEMBL5092128 | — | — | 1 | 8.70 |
| CHEMBL5076933 | — | — | 2 | 8.70 |
| CHEMBL5081751 | — | — | 2 | 8.52 |
| CHEMBL5079022 | — | — | 1 | 8.52 |
| CHEMBL5075027 | — | — | 2 | 8.40 |
| CHEMBL5083176 | — | — | 1 | 8.30 |
| CHEMBL5076655 | — | — | 2 | 8.30 |
| CHEMBL5084545 | — | — | 1 | 8.22 |
| CHEMBL5074724 | — | — | 1 | 8.22 |
| CHEMBL5094941 | — | — | 1 | 8.15 |
| CHEMBL5086490 | — | — | 1 | 8.15 |
| CHEMBL5089490 | — | — | 1 | 8.15 |
| CHEMBL5079067 | — | — | 2 | 8.15 |
| CHEMBL5080236 | — | — | 2 | 8.15 |
| CHEMBL5085587 | — | — | 2 | 8.10 |
| CHEMBL5089138 | — | — | 1 | 8.10 |
| CHEMBL5085397 | — | — | 1 | 8.10 |
| CHEMBL5073204 | — | — | 2 | 8.00 |
| CHEMBL5082318 | — | — | 3 | 8.00 |
| CHEMBL5080965 | — | — | 1 | 8.00 |
| CHEMBL5070191 | — | — | 3 | 8.00 |
| CHEMBL5090975 | — | — | 1 | 8.00 |
| CHEMBL5087767 | — | — | 1 | 7.92 |
| CHEMBL5078331 | — | — | 1 | 7.92 |
| CHEMBL5076934 | — | — | 1 | 7.92 |
| CHEMBL5082898 | — | — | 1 | 7.89 |
| CHEMBL5080480 | — | — | 2 | 7.89 |
| CHEMBL5076367 | — | — | 1 | 7.85 |
| CHEMBL5075874 | — | — | 2 | 7.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5092128 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL5075231 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL5076933 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL5081751 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL5079022 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL5075027 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL5075231 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL5075027 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL5081751 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL5083176 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL5076655 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL5084545 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL5074724 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL5086490 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL5079067 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL5094941 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL5080236 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL5089490 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL5089138 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL5085587 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL5076933 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL5085397 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL5073204 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL5080965 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL5082318 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL5082318 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL5090975 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL5070191 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL5079067 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL5078331 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL5087767 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL5076934 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL5082898 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL5080480 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL5080236 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL5076367 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL5076433 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL5075874 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL5076979 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL5086405 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL5094223 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL5082998 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL5076655 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL5069765 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL5073826 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL5086874 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL5075060 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL5084465 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL5077651 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL5092149 | — | IC50 | = | 26.0 | nM | 7.58 |