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Assay Detail

CHEMBL5053385

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of recombinant rat/human ADAMTS12 hybrid using HiLyteFluor-488 DELSSMVLELRGLRT-K(QXL520)-E-NH2 as substrate incubated for 120 mins and measured by FRET assay
ChEMBL ↗
160
Total Activities
122
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545) ↗
Type UNCHECKED

Publication

Substituted hydantoinamides as adamts7 antagonists
(2021)

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 160 5.42 7.39

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5092128 — — 1 7.39
CHEMBL5079022 — — 1 7.34
CHEMBL5081751 — — 2 6.97
CHEMBL5075231 — — 2 6.89
CHEMBL5094941 — — 1 6.76
CHEMBL5076933 — — 2 6.70
CHEMBL5083176 — — 1 6.60
CHEMBL5089490 — — 1 6.51
CHEMBL5075027 — — 2 6.50
CHEMBL5076655 — — 2 6.40
CHEMBL5086874 — — 1 6.35
CHEMBL5089138 — — 1 6.34
CHEMBL5092149 — — 1 6.32
CHEMBL5087767 — — 1 6.30
CHEMBL5082898 — — 1 6.24
CHEMBL5088951 — — 1 6.22
CHEMBL5078331 — — 1 6.22
CHEMBL5075874 — — 2 6.11
CHEMBL5074724 — — 1 6.05
CHEMBL5078707 — — 1 6.04
CHEMBL5079067 — — 2 6.04
CHEMBL5085716 — — 1 6.02
CHEMBL5084545 — — 1 6.01
CHEMBL5080965 — — 1 6.01
CHEMBL5070191 — — 3 6.00
CHEMBL5080236 — — 2 6.00
CHEMBL5072115 — — 1 6.00
CHEMBL5084465 — — 1 5.96
CHEMBL5086018 — — 1 5.85
CHEMBL5077651 — — 1 5.85

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5092128 — IC50 = 41.0 nM 7.39
CHEMBL5079022 — IC50 = 46.0 nM 7.34
CHEMBL5081751 — IC50 = 108.0 nM 6.97
CHEMBL5075231 — IC50 = 130.0 nM 6.89
CHEMBL5094941 — IC50 = 175.0 nM 6.76
CHEMBL5076933 — IC50 = 200.0 nM 6.70
CHEMBL5081751 — IC50 = 200.0 nM 6.70
CHEMBL5083176 — IC50 = 250.0 nM 6.60
CHEMBL5089490 — IC50 = 310.0 nM 6.51
CHEMBL5075231 — IC50 = 320.0 nM 6.50
CHEMBL5075027 — IC50 = 320.0 nM 6.50
CHEMBL5075027 — IC50 = 360.0 nM 6.44
CHEMBL5076655 — IC50 = 400.0 nM 6.40
CHEMBL5086874 — IC50 = 450.0 nM 6.35
CHEMBL5089138 — IC50 = 460.0 nM 6.34
CHEMBL5092149 — IC50 = 480.0 nM 6.32
CHEMBL5087767 — IC50 = 500.0 nM 6.30
CHEMBL5082898 — IC50 = 580.0 nM 6.24
CHEMBL5078331 — IC50 = 600.0 nM 6.22
CHEMBL5088951 — IC50 = 600.0 nM 6.22
CHEMBL5076933 — IC50 = 680.0 nM 6.17
CHEMBL5075874 — IC50 = 780.0 nM 6.11
CHEMBL5074724 — IC50 = 890.0 nM 6.05
CHEMBL5079067 — IC50 = 910.0 nM 6.04
CHEMBL5078707 — IC50 = 910.0 nM 6.04
CHEMBL5085716 — IC50 = 950.0 nM 6.02
CHEMBL5084545 — IC50 = 975.0 nM 6.01
CHEMBL5080965 — IC50 = 980.0 nM 6.01
CHEMBL5080236 — IC50 = 1000.0 nM 6.00
CHEMBL5070191 — IC50 = 1000.0 nM 6.00
CHEMBL5072115 — IC50 = 1000.0 nM 6.00
CHEMBL5084465 — IC50 = 1100.0 nM 5.96
CHEMBL5076655 — IC50 = 1100.0 nM 5.96
CHEMBL5075874 — IC50 = 1200.0 nM 5.92
CHEMBL5076979 — IC50 = 1400.0 nM 5.85
CHEMBL5086018 — IC50 = 1400.0 nM 5.85
CHEMBL5077651 — IC50 = 1420.0 nM 5.85
CHEMBL5085514 — IC50 = 1450.0 nM 5.84
CHEMBL5083544 — IC50 = 1500.0 nM 5.82
CHEMBL5082998 — IC50 = 1700.0 nM 5.77
CHEMBL5070872 — IC50 = 1700.0 nM 5.77
CHEMBL5094223 — IC50 = 1800.0 nM 5.75
CHEMBL5076179 — IC50 = 1800.0 nM 5.75
CHEMBL5082318 — IC50 = 1900.0 nM 5.72
CHEMBL5074569 — IC50 = 2000.0 nM 5.70
CHEMBL5082882 — IC50 = 2200.0 nM 5.66
CHEMBL5075426 — IC50 = 2200.0 nM 5.66
CHEMBL5076037 — IC50 = 2200.0 nM 5.66
CHEMBL5085397 — IC50 = 2200.0 nM 5.66
CHEMBL5070191 — IC50 = 2200.0 nM 5.66