Assay Detail
Binding
CHEMBL5053473
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant rat GCH1 assessed as reduction in 7,8-dihydroneoptrein 3'-triphosphate formation using GTP as substrate incubated for 15 mins by HPLC and fluorescence detection assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Heterocyclic GTP Cyclohydrolase 1 Inhibitors For the Treatment of Pain
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 4.65 | 4.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL374107 | 8-AZAGUANINE | — | 1 | 4.68 |
| CHEMBL178006 | — | — | 1 | 4.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL374107 | 8-AZAGUANINE | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL178006 | — | IC50 | = | 24000.0 | nM | 4.62 |