Assay Detail
Binding
CHEMBL5053561
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of 2-FAM-InsP5 binding to human SHIP2 catalytic domain (419 to 832 residues) assessed as change in polarization by fluorescence polarization based displacement assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 (CHEMBL2331064) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Allosteric Site on SHIP2 Identified Through Fluorescent Ligand Screening and Crystallography: A Potential New Target for Intervention.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 6.28 | 7.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5087243 | — | — | 1 | 7.64 |
| CHEMBL5078323 | — | — | 1 | 7.57 |
| CHEMBL5092991 | — | — | 1 | 7.54 |
| CHEMBL5080660 | — | — | 1 | 7.51 |
| CHEMBL5081948 | — | — | 1 | 7.21 |
| CHEMBL5092487 | — | — | 1 | 5.81 |
| CHEMBL23552 | — | — | 1 | 5.64 |
| CHEMBL66953 | PURPUROGALLIN | — | 1 | 5.26 |
| CHEMBL601719 | CRIZOTINIB | 4.0 | 1 | 5.26 |
| CHEMBL4473747 | — | — | 1 | 5.20 |
| CHEMBL1756 | ESTRAMUSTINE PHOSPHATE | 4.0 | 1 | 4.45 |
| CHEMBL1601846 | — | — | 1 | - |
| CHEMBL234338 | — | — | 1 | - |
| CHEMBL2337806 | — | — | 1 | - |
| CHEMBL5094588 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5087243 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL5078323 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL5092991 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL5080660 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL5081948 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL5092487 | — | IC50 | = | 1540.0 | nM | 5.81 |
| CHEMBL23552 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL66953 | PURPUROGALLIN | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL601719 | CRIZOTINIB | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL4473747 | — | IC50 | = | 6250.0 | nM | 5.20 |
| CHEMBL1756 | ESTRAMUSTINE PHOSPHATE | IC50 | = | 35500.0 | nM | 4.45 |
| CHEMBL1601846 | — | IC50 | - | — | - | |
| CHEMBL234338 | — | IC50 | - | — | - | |
| CHEMBL2337806 | — | IC50 | - | — | - | |
| CHEMBL5094588 | — | IC50 | > | 100000.0 | nM | - |