Assay Detail
Binding
CHEMBL5053568
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of SHIP2 in serum-starved mouse Mm1 cells assessed as reduction in Akt phosphorylation incubated for 30 mins by Western blot analysis
3
Total Activities
3
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | Mm1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 (CHEMBL2331063) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
Allosteric Site on SHIP2 Identified Through Fluorescent Ligand Screening and Crystallography: A Potential New Target for Intervention.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Inhibition | 2 | - | - |
| IC50 | 1 | 6.41 | 6.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4538474 | — | — | 1 | 6.41 |
| CHEMBL66953 | PURPUROGALLIN | — | 1 | - |
| CHEMBL2337806 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4538474 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL66953 | PURPUROGALLIN | Inhibition | - | % | - | |
| CHEMBL2337806 | — | Inhibition | - | % | - |