Assay Detail
Functional
CHEMBL5053579
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Cardioprotective activity against DAU-induced cardiotoxicity in Wistar rat neonatal ventricular cardiomyocytes preincubated for 3 hrs followed by DAU addition for 3 hrs and further incubated for 48 hrs in drug free medium by LDH assay
6
Total Activities
6
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | Neonatal ventricular cardiomyocytes |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Structure-Activity Relationship Study of Dexrazoxane Analogues Reveals ICRF-193 as the Most Potent Bisdioxopiperazine against Anthracycline Toxicity to Cardiomyocytes Due to Its Strong Topoisomerase IIβ Interactions.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Activity | 3 | - | - |
| EC50 | 3 | 5.40 | 5.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5083245 | — | — | 1 | 5.40 |
| CHEMBL5084324 | — | — | 1 | - |
| CHEMBL5085267 | — | — | 1 | - |
| CHEMBL5079198 | — | — | 1 | - |
| CHEMBL5076925 | — | — | 1 | - |
| CHEMBL1738 | DEXRAZOXANE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5083245 | — | EC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL5084324 | — | Activity | - | — | - | |
| CHEMBL5085267 | — | Activity | - | — | - | |
| CHEMBL5079198 | — | Activity | - | — | - | |
| CHEMBL5076925 | — | EC50 | = | 174000.0 | nM | - |
| CHEMBL1738 | DEXRAZOXANE | EC50 | = | 101000.0 | nM | - |