Assay Detail
Functional
CHEMBL5053607
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Induction of cell differentiation in human U-937 cells assessed as CD11b expression after 3 days by flow cytometric analysis
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | U-937 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Targeting Acute Myelogenous Leukemia Using Potent Human Dihydroorotate Dehydrogenase Inhibitors Based on the 2-Hydroxypyrazolo[1,5-<i>a</i>]pyridine Scaffold: SAR of the Biphenyl Moiety.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 7.58 | 8.34 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5090281 | — | — | 1 | 8.34 |
| CHEMBL5090431 | — | — | 1 | 8.07 |
| CHEMBL4173846 | — | — | 1 | 7.58 |
| CHEMBL5084878 | — | — | 1 | 7.51 |
| CHEMBL5078949 | — | — | 1 | 7.47 |
| CHEMBL5092556 | — | — | 1 | 7.39 |
| CHEMBL38434 | BREQUINAR | 2.0 | 1 | 6.72 |
| CHEMBL5077508 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5090281 | — | EC50 | = | 4.6 | nM | 8.34 |
| CHEMBL5090431 | — | EC50 | = | 8.6 | nM | 8.07 |
| CHEMBL4173846 | — | EC50 | = | 26.0 | nM | 7.58 |
| CHEMBL5084878 | — | EC50 | = | 31.1 | nM | 7.51 |
| CHEMBL5078949 | — | EC50 | = | 34.2 | nM | 7.47 |
| CHEMBL5092556 | — | EC50 | = | 40.7 | nM | 7.39 |
| CHEMBL38434 | BREQUINAR | EC50 | = | 188.6 | nM | 6.72 |
| CHEMBL5077508 | — | EC50 | - | — | - |