Assay Detail
Binding
CHEMBL5053800
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of TRKA L657M mutant (unknown origin) in presence of [gamma-33P]ATP by hotspot kinase assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Design and synthesis of novel orally selective and type II pan-TRK inhibitors to overcome mutations by property-driven optimization.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 8.06 | 8.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5089809 | — | — | 1 | 8.43 |
| CHEMBL4856292 | — | — | 1 | 7.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5089809 | — | IC50 | = | 3.74 | nM | 8.43 |
| CHEMBL4856292 | — | IC50 | = | 20.7 | nM | 7.68 |