Assay Detail
Binding
CHEMBL5054018
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Displacement of [3H]5-CT from human recombinant 5-HT7A receptor expressed in HEK cells by radioligand completion assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Activity of <i>Mitragyna speciosa</i> ("Kratom") Alkaloids at Serotonin Receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 6.39 | 8.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL39 | SEROTONIN | 3.0 | 1 | 8.68 |
| CHEMBL4848517 | — | — | 1 | 6.06 |
| CHEMBL4859858 | — | — | 1 | 5.80 |
| CHEMBL299031 | — | — | 1 | 5.00 |
| CHEMBL5072247 | — | — | 1 | - |
| CHEMBL5089613 | — | — | 1 | - |
| CHEMBL8412 | IPSAPIRONE | 2.0 | 1 | - |
| CHEMBL56 | 8-OH-DPAT | — | 1 | - |
| CHEMBL134519 | — | — | 1 | - |
| CHEMBL31354 | WAY-100,635 | — | 1 | - |
| CHEMBL297784 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL39 | SEROTONIN | Ki | = | 2.1 | nM | 8.68 |
| CHEMBL4848517 | — | Ki | = | 870.0 | nM | 6.06 |
| CHEMBL4859858 | — | Ki | = | 1600.0 | nM | 5.80 |
| CHEMBL299031 | — | Ki | = | 10000.0 | nM | 5.00 |
| CHEMBL5072247 | — | Ki | - | — | - | |
| CHEMBL5089613 | — | Ki | - | — | - | |
| CHEMBL8412 | IPSAPIRONE | Ki | - | — | - | |
| CHEMBL56 | 8-OH-DPAT | Ki | - | — | - | |
| CHEMBL134519 | — | Ki | - | — | - | |
| CHEMBL31354 | WAY-100,635 | Ki | - | — | - | |
| CHEMBL297784 | — | Ki | - | — | - |