Assay Detail
ADMET
CHEMBL5054271
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Cytotoxicity against platelets in human PRP assessed as reduction in cell viability measured after 48 hrs by MTS assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | Platelet |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of a Novel BCL-X<sub>L</sub> PROTAC Degrader with Enhanced BCL-2 Inhibition.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.77 | 6.49 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL443684 | NAVITOCLAX | 3.0 | 1 | 6.49 |
| CHEMBL5077514 | — | — | 1 | 6.02 |
| CHEMBL5086468 | — | — | 1 | 5.54 |
| CHEMBL5073297 | — | — | 1 | 5.01 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL443684 | NAVITOCLAX | IC50 | = | 325.0 | nM | 6.49 |
| CHEMBL5077514 | — | IC50 | = | 950.0 | nM | 6.02 |
| CHEMBL5086468 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL5073297 | — | IC50 | = | 9850.0 | nM | 5.01 |