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Assay Detail

CHEMBL5054366

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Anticancer activity against human JJN3R cells
ChEMBL ↗
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type JJN-3R
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545) ↗
Type UNCHECKED

Publication

Discovery and Preclinical Pharmacology of an Oral Bromodomain and Extra-Terminal (BET) Inhibitor Using Scaffold-Hopping and Structure-Guided Drug Design.
Gavai AV, Norris D, Delucca G, Tortolani D, Tokarski JS, Dodd D, O'Malley D, Zhao Y, Quesnelle C, Gill P, Vaccaro W, Huynh T, Ahuja V, Han WC, Mussari C, Harikrishnan L, Kamau M, Poss M, Sheriff S, Yan C, Marsilio F, Menard K, Wen ML, Rampulla R, Wu DR, Li J, Zhang H, Li P, Sun D, Yip H, Traeger SC, Zhang Y, Mathur A, Zhang H, Huang C, Yang Z, Ranasinghe A, Everlof G, Raghavan N, Tye CK, Wee S, Hunt JT, Vite G, Westhouse R, Lee FY.
J Med Chem (2021) 64 : 14247 -14265
PubMed 34543572 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 1 9.15 9.15

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4297458 EZOBRESIB 2.0 1 9.15

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4297458 EZOBRESIB IC50 = 0.7 nM 9.15