Assay Detail
Functional
CHEMBL5054476
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Cytotoxicity against human JHH7 cells assessed as cell viability by MTT assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | JHH7 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Cinchona Alkaloid-Inspired Urea-Containing Autophagy Inhibitor Shows Single-Agent Anticancer Efficacy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.89 | 6.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5082200 | — | — | 1 | 6.57 |
| CHEMBL5070688 | — | — | 1 | 6.47 |
| CHEMBL5072373 | — | — | 1 | 6.38 |
| CHEMBL5074131 | — | — | 1 | 6.22 |
| CHEMBL5086941 | — | — | 1 | 5.23 |
| CHEMBL5083641 | — | — | 1 | 5.19 |
| CHEMBL5079763 | — | — | 1 | 5.14 |
| CHEMBL5074244 | — | — | 1 | - |
| CHEMBL5080116 | — | — | 1 | - |
| CHEMBL5094219 | — | — | 1 | - |
| CHEMBL5091354 | — | — | 1 | - |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5082200 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL5070688 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL5072373 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL5074131 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL5086941 | — | IC50 | = | 5870.0 | nM | 5.23 |
| CHEMBL5083641 | — | IC50 | = | 6420.0 | nM | 5.19 |
| CHEMBL5079763 | — | IC50 | = | 7310.0 | nM | 5.14 |
| CHEMBL5074244 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5080116 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5094219 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5091354 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL76 | CHLOROQUINE | IC50 | > | 10000.0 | nM | - |