Assay Detail
Binding
CHEMBL5055008
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Displacement of [3H]-DPDPE from human delta opioid receptor expressed in mouse HN9.10 cells assessed as inhibition constant by radioligand binding assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HN9.10 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
C-terminal modified Enkephalin-like tetrapeptides with enhanced affinities at the kappa opioid receptor and monoamine transporters.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 8.77 | 9.49 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5089012 | — | — | 1 | 9.49 |
| CHEMBL5094499 | — | — | 1 | 9.27 |
| CHEMBL5091642 | — | — | 1 | 9.24 |
| CHEMBL5086370 | — | — | 1 | 9.24 |
| CHEMBL5078669 | — | — | 1 | 9.13 |
| CHEMBL5081245 | — | — | 1 | 8.96 |
| CHEMBL5090705 | — | — | 1 | 8.92 |
| CHEMBL5083183 | — | — | 1 | 8.68 |
| CHEMBL2311114 | — | — | 1 | 8.62 |
| CHEMBL5077561 | — | — | 1 | 8.44 |
| CHEMBL235743 | — | — | 1 | 6.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5089012 | — | Ki | = | 0.32 | nM | 9.49 |
| CHEMBL5094499 | — | Ki | = | 0.54 | nM | 9.27 |
| CHEMBL5091642 | — | Ki | = | 0.57 | nM | 9.24 |
| CHEMBL5086370 | — | Ki | = | 0.58 | nM | 9.24 |
| CHEMBL5078669 | — | Ki | = | 0.74 | nM | 9.13 |
| CHEMBL5081245 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL5090705 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL5083183 | — | Ki | = | 2.1 | nM | 8.68 |
| CHEMBL2311114 | — | Ki | = | 2.4 | nM | 8.62 |
| CHEMBL5077561 | — | Ki | = | 3.6 | nM | 8.44 |
| CHEMBL235743 | — | Ki | = | 300.0 | nM | 6.52 |