Assay Detail
Binding
CHEMBL5055384
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to wild-type human partial length AKT3 expressed in bacterial expression system assessed as residual binding level by Kinomescan method
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
RAC-gamma serine/threonine-protein kinase (CHEMBL4816) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design, Synthesis, and Evaluation of Potent, Selective, and Bioavailable AKT Kinase Degraders.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 5 | 8.24 | 8.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2177390 | IPATASERTIB | 3.0 | 1 | 8.60 |
| CHEMBL5073195 | — | — | 1 | 8.38 |
| CHEMBL5091595 | — | — | 1 | 8.19 |
| CHEMBL5078362 | — | — | 1 | 8.09 |
| CHEMBL5082198 | — | — | 1 | 7.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2177390 | IPATASERTIB | Kd | = | 2.5 | nM | 8.60 |
| CHEMBL5073195 | — | Kd | = | 4.2 | nM | 8.38 |
| CHEMBL5091595 | — | Kd | = | 6.5 | nM | 8.19 |
| CHEMBL5078362 | — | Kd | = | 8.1 | nM | 8.09 |
| CHEMBL5082198 | — | Kd | = | 12.0 | nM | 7.92 |