Assay Detail
Binding
CHEMBL5055751
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Antagonist activity at human TRPA1 expressed in CHO cells assessed as cinnamaldehyde-induced calcium flux measured after 90 mins by FLIPR assay
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Tetrahydrofuran-Based Transient Receptor Potential Ankyrin 1 (TRPA1) Antagonists: Ligand-Based Discovery, Activity in a Rodent Asthma Model, and Mechanism-of-Action via Cryogenic Electron Microscopy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 7.62 | 9.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4849329 | — | — | 1 | 9.05 |
| CHEMBL5079912 | — | — | 1 | 8.72 |
| CHEMBL5089337 | — | — | 1 | 8.70 |
| CHEMBL4870870 | — | — | 1 | 8.54 |
| CHEMBL5076999 | — | — | 1 | 8.14 |
| CHEMBL5093753 | — | — | 1 | 8.13 |
| CHEMBL5076509 | — | — | 1 | 8.12 |
| CHEMBL5094919 | — | — | 1 | 8.09 |
| CHEMBL5091195 | — | — | 1 | 8.02 |
| CHEMBL5093218 | — | — | 1 | 7.85 |
| CHEMBL4863686 | — | — | 1 | 7.70 |
| CHEMBL5091060 | — | — | 1 | 7.60 |
| CHEMBL5070446 | — | — | 1 | 7.50 |
| CHEMBL5088024 | — | — | 1 | 7.30 |
| CHEMBL5092342 | — | — | 1 | 7.27 |
| CHEMBL5084582 | — | — | 1 | 7.12 |
| CHEMBL3785736 | — | — | 1 | 7.00 |
| CHEMBL5081153 | — | — | 1 | 6.39 |
| CHEMBL5089815 | — | — | 1 | 5.72 |
| CHEMBL5084460 | — | — | 1 | 5.34 |
| CHEMBL5080698 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4849329 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL5079912 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL5089337 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4870870 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL5076999 | — | IC50 | = | 7.3 | nM | 8.14 |
| CHEMBL5093753 | — | IC50 | = | 7.4 | nM | 8.13 |
| CHEMBL5076509 | — | IC50 | = | 7.6 | nM | 8.12 |
| CHEMBL5094919 | — | IC50 | = | 8.1 | nM | 8.09 |
| CHEMBL5091195 | — | IC50 | = | 9.6 | nM | 8.02 |
| CHEMBL5093218 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL4863686 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL5091060 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL5070446 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL5088024 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL5092342 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL5084582 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL3785736 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL5081153 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL5089815 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL5084460 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL5080698 | — | IC50 | > | 20000.0 | nM | - |