Assay Detail
Binding
CHEMBL5055971
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Positive allosteric modulation of human recombinant alpha4beta1delta GABAA receptor expressed in delta-HEK cells assessed as potentiation of GABA-induced response in presence of GABA EC20 by FMP assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Gamma-aminobutyric acid receptor subunit alpha-4/beta-1/delta (CHEMBL4523639) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Structural Determinants for the Mode of Action of Imidazopyridine DS2 at δ-Containing γ-Aminobutyric Acid Type A Receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 6.43 | 7.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5072077 | — | — | 1 | 7.22 |
| CHEMBL5088746 | — | — | 1 | 6.85 |
| CHEMBL5081682 | — | — | 1 | 6.80 |
| CHEMBL4212818 | — | — | 1 | 6.01 |
| CHEMBL5090382 | — | — | 1 | 5.96 |
| CHEMBL5069550 | — | — | 1 | 5.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5072077 | — | EC50 | = | 60.0 | nM | 7.22 |
| CHEMBL5088746 | — | EC50 | = | 140.0 | nM | 6.85 |
| CHEMBL5081682 | — | EC50 | = | 160.0 | nM | 6.80 |
| CHEMBL4212818 | — | EC50 | = | 980.0 | nM | 6.01 |
| CHEMBL5090382 | — | EC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL5069550 | — | EC50 | = | 1920.0 | nM | 5.72 |