Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL5056334

Review assay metadata, readout intent, target linkage, and publication context from the same page.

ADMET
Cytotoxicity against human HBL-100 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type ADMET
Organism Homo sapiens
Cell Type HBL-100
Confidence 1 — Organism
Curated By Autocuration

Target

HBL-100 (CHEMBL614811)
Type CELL-LINE
Organism Homo sapiens

Publication

Nitric Oxide Photo-Donor Hybrids of Ciprofloxacin and Norfloxacin: A Shift in Activity from Antimicrobial to Anticancer Agents.
Fallica AN, Barbaraci C, Amata E, Pasquinucci L, Turnaturi R, Dichiara M, Intagliata S, Gariboldi MB, Marras E, Orlandi VT, Ferroni C, Martini C, Rescifina A, Gentile D, Varchi G, Marrazzo A.
J Med Chem (2021) 64 : 11597 -11613
PubMed 34319100 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 14 5.02 5.43

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5078222 1 5.43
CHEMBL5080830 1 5.11
CHEMBL5087376 1 5.04
CHEMBL5071506 1 5.04
CHEMBL5086950 1 5.03
CHEMBL5089126 1 5.01
CHEMBL8 CIPROFLOXACIN 4.0 1 4.99
CHEMBL5089495 1 4.98
CHEMBL5087868 1 4.98
CHEMBL5090363 1 4.96
CHEMBL5088220 1 4.96
CHEMBL5070696 1 4.92
CHEMBL5078988 1 4.91
CHEMBL9 NORFLOXACIN 4.0 1 4.91

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5078222 IC50 = 3680.0 nM 5.43
CHEMBL5080830 IC50 = 7790.0 nM 5.11
CHEMBL5087376 IC50 = 9140.0 nM 5.04
CHEMBL5071506 IC50 = 9190.0 nM 5.04
CHEMBL5086950 IC50 = 9260.0 nM 5.03
CHEMBL5089126 IC50 = 9760.0 nM 5.01
CHEMBL8 CIPROFLOXACIN IC50 = 10280.0 nM 4.99
CHEMBL5089495 IC50 = 10570.0 nM 4.98
CHEMBL5087868 IC50 = 10400.0 nM 4.98
CHEMBL5090363 IC50 = 10850.0 nM 4.96
CHEMBL5088220 IC50 = 11090.0 nM 4.96
CHEMBL5070696 IC50 = 11950.0 nM 4.92
CHEMBL5078988 IC50 = 12210.0 nM 4.91
CHEMBL9 NORFLOXACIN IC50 = 12430.0 nM 4.91