Assay Detail
Binding
CHEMBL5056449
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Sprague-Dawley rat brain microsome HO-2 assessed as bilirubin formation incubated for 60 mins by double-beam spectrophotometry
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Subcellular | Microsome |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of Novel Acetamide-Based Heme Oxygenase-1 Inhibitors with Potent <i>In Vitro</i> Antiproliferative Activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 5.22 | 6.34 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4166126 | — | — | 1 | 6.34 |
| CHEMBL5081981 | — | — | 1 | 6.05 |
| CHEMBL5090796 | — | — | 1 | 5.96 |
| CHEMBL5089882 | — | — | 1 | 5.92 |
| CHEMBL1188481 | — | — | 1 | 4.95 |
| CHEMBL5074613 | — | — | 1 | 4.95 |
| CHEMBL4534531 | — | — | 1 | 4.84 |
| CHEMBL5079136 | — | — | 1 | 4.80 |
| CHEMBL70611 | AZALANSTAT | 2.0 | 1 | 4.61 |
| CHEMBL5075602 | — | — | 1 | 4.61 |
| CHEMBL5082833 | — | — | 1 | 4.34 |
| CHEMBL5092763 | — | — | 1 | - |
| CHEMBL5072992 | — | — | 1 | - |
| CHEMBL4571673 | — | — | 1 | - |
| CHEMBL5078606 | — | — | 1 | - |
| CHEMBL5090858 | — | — | 1 | - |
| CHEMBL5089974 | — | — | 1 | - |
| CHEMBL5091180 | — | — | 1 | - |
| CHEMBL563814 | — | — | 1 | - |
| CHEMBL5071354 | — | — | 1 | - |
| CHEMBL5093716 | — | — | 1 | - |
| CHEMBL5079290 | — | — | 1 | - |
| CHEMBL5083975 | — | — | 1 | - |
| CHEMBL5084092 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4166126 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL5081981 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL5090796 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL5089882 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL1188481 | — | IC50 | = | 11300.0 | nM | 4.95 |
| CHEMBL5074613 | — | IC50 | = | 11190.0 | nM | 4.95 |
| CHEMBL4534531 | — | IC50 | = | 14400.0 | nM | 4.84 |
| CHEMBL5079136 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL70611 | AZALANSTAT | IC50 | = | 24400.0 | nM | 4.61 |
| CHEMBL5075602 | — | IC50 | = | 24710.0 | nM | 4.61 |
| CHEMBL5082833 | — | IC50 | = | 45890.0 | nM | 4.34 |
| CHEMBL5092763 | — | IC50 | - | — | - | |
| CHEMBL5072992 | — | IC50 | - | — | - | |
| CHEMBL4571673 | — | IC50 | - | — | - | |
| CHEMBL5078606 | — | IC50 | - | — | - | |
| CHEMBL5090858 | — | IC50 | - | — | - | |
| CHEMBL5089974 | — | IC50 | - | — | - | |
| CHEMBL5091180 | — | IC50 | - | — | - | |
| CHEMBL563814 | — | IC50 | - | — | - | |
| CHEMBL5071354 | — | IC50 | - | — | - | |
| CHEMBL5093716 | — | IC50 | - | — | - | |
| CHEMBL5079290 | — | IC50 | - | — | - | |
| CHEMBL5083975 | — | IC50 | - | — | - | |
| CHEMBL5084092 | — | IC50 | - | — | - |