Assay Detail
Functional
CHEMBL5056547
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Chemo-sensitizing activity against human KB 3-1 cells assessed as vincristine IC50 at 2 uM measured after 72 hrs in presence of vincristine by CCK8 assay (Rvb = 1.19 +/-0.39 nM)
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | KB 3-1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 9.01 | 9.01 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL243148 | SOPHORAFLAVANONE G | — | 1 | 9.01 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL243148 | SOPHORAFLAVANONE G | IC50 | = | 0.97 | nM | 9.01 |