Assay Detail

CHEMBL5056649

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional

Chemo-sensitizing activity against human KB 3-1 cells assessed as paclitaxel IC50 at 1 uM measured after 72 hrs in presence of paclitaxel by CCK8 assay (Rvb = 2.29 +/-0.75 nM)

ChEMBL ↗

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Target

KB 3-1 (CHEMBL614590) ↗

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KB 3-1 (CHEMBL614590) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target KB 3-1

CHEMBL614590

Anchored from Assay target.

Protein identity KB 3-1

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	KB 3-1
Confidence	1 — Organism
Curated By	Autocuration

Target

KB 3-1 (CHEMBL614590) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

Sophoraflavanone G Resensitizes ABCG2-Overexpressing Multidrug-Resistant Non-Small-Cell Lung Cancer Cells to Chemotherapeutic Drugs.

Wu CP, Li YQ, Hung TH, Chang YT, Huang YH, Wu YS.
J Nat Prod (2021) 84 : 2544 -2553
PubMed 34496204 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	2	8.60	8.61

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL348475	TARIQUIDAR	3.0	1	8.61
CHEMBL243148	SOPHORAFLAVANONE G	—	1	8.59

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL348475	TARIQUIDAR	IC50	=	2.45	nM	8.61
CHEMBL243148	SOPHORAFLAVANONE G	IC50	=	2.6	nM	8.59