Assay Detail
ADMET
CHEMBL5056947
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Potentiation of paclitaxel-induced cytotoxicity against human MDA-MB-231 cells expressing TLR4 assessed as growth inhibition by measuring PTX IC50 at 0.1 uM pretreated with compound for 24 hrs followed by PTX challenge measured after 72 hrs by MTT assay (Rvb = 0.027 +/- 0.012 microM)
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-231 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis of small molecules targeting paclitaxel-induced MyD88 expression in triple-negative breast cancer cell lines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 7.58 | 7.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3601750 | — | — | 1 | 7.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3601750 | — | IC50 | = | 26.0 | nM | 7.58 |