Assay Detail
Functional
CHEMBL5056952
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Potentiation of paclitaxel-induced cytotoxicity against human HCC1806 cells assessed as growth inhibition by measuring PTX IC50 at 1 uM pretreated with compound for 24 hrs followed by PTX challenge measured after 72 hrs by MTT assay (Rvb = 0.008 microM)
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCC1806 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis of small molecules targeting paclitaxel-induced MyD88 expression in triple-negative breast cancer cell lines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 8.15 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3601750 | — | — | 1 | 8.15 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3601750 | — | IC50 | = | 7.0 | nM | 8.15 |