Assay Detail
Functional
CHEMBL5058435
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Antitumor activity against human spontaneously immortalized CDH-/- MCF10A cells assessed as cell numbers measured after 48 hrs
64
Total Activities
64
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF-10A |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of AL-GDa62 as a Potential Synthetic Lethal Lead for the Treatment of Gastric Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 64 | 5.06 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4170114 | — | — | 1 | 6.70 |
| CHEMBL5078418 | — | — | 1 | 5.96 |
| CHEMBL5093223 | — | — | 1 | 5.77 |
| CHEMBL5077092 | — | — | 1 | 5.75 |
| CHEMBL5080042 | — | — | 1 | 5.75 |
| CHEMBL5074622 | — | — | 1 | 5.72 |
| CHEMBL5088428 | — | — | 1 | 5.72 |
| CHEMBL5074766 | — | — | 1 | 5.70 |
| CHEMBL5080319 | — | — | 1 | 5.57 |
| CHEMBL5085285 | — | — | 1 | 5.55 |
| CHEMBL5092470 | — | — | 1 | 5.55 |
| CHEMBL5089884 | — | — | 1 | 5.44 |
| CHEMBL588320 | — | — | 1 | 5.39 |
| CHEMBL5087382 | — | — | 1 | 5.39 |
| CHEMBL5074049 | — | — | 1 | 5.28 |
| CHEMBL5072843 | — | — | 1 | 5.19 |
| CHEMBL5093931 | — | — | 1 | 5.16 |
| CHEMBL1304000 | — | — | 1 | 5.16 |
| CHEMBL1371194 | — | — | 1 | 5.14 |
| CHEMBL5078785 | — | — | 1 | 5.12 |
| CHEMBL5073946 | — | — | 1 | 5.11 |
| CHEMBL5087221 | — | — | 1 | 5.09 |
| CHEMBL1407436 | — | — | 1 | 5.09 |
| CHEMBL5082073 | — | — | 1 | 5.08 |
| CHEMBL5074005 | — | — | 1 | 5.08 |
| CHEMBL5075635 | — | — | 1 | 5.07 |
| CHEMBL5077733 | — | — | 1 | 5.06 |
| CHEMBL5077707 | — | — | 1 | 5.05 |
| CHEMBL5081750 | — | — | 1 | 5.04 |
| CHEMBL5079494 | — | — | 1 | 5.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4170114 | — | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL5078418 | — | EC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL5093223 | — | EC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL5077092 | — | EC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL5080042 | — | EC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL5074622 | — | EC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL5088428 | — | EC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL5074766 | — | EC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL5080319 | — | EC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL5085285 | — | EC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL5092470 | — | EC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL5089884 | — | EC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL588320 | — | EC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL5087382 | — | EC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL5074049 | — | EC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL5072843 | — | EC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL5093931 | — | EC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL1304000 | — | EC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL1371194 | — | EC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL5078785 | — | EC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL5073946 | — | EC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL5087221 | — | EC50 | = | 8100.0 | nM | 5.09 |
| CHEMBL1407436 | — | EC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL5082073 | — | EC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL5074005 | — | EC50 | = | 8400.0 | nM | 5.08 |
| CHEMBL5075635 | — | EC50 | = | 8500.0 | nM | 5.07 |
| CHEMBL5077733 | — | EC50 | = | 8800.0 | nM | 5.06 |
| CHEMBL5077707 | — | EC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL5081750 | — | EC50 | = | 9100.0 | nM | 5.04 |
| CHEMBL5079494 | — | EC50 | = | 9500.0 | nM | 5.02 |
| CHEMBL5094449 | — | EC50 | = | 9700.0 | nM | 5.01 |
| CHEMBL5075642 | — | EC50 | = | 9800.0 | nM | 5.01 |
| CHEMBL5077682 | — | EC50 | = | 10300.0 | nM | 4.99 |
| CHEMBL5081393 | — | EC50 | = | 10200.0 | nM | 4.99 |
| CHEMBL5079296 | — | EC50 | = | 10400.0 | nM | 4.98 |
| CHEMBL5083013 | — | EC50 | = | 11300.0 | nM | 4.95 |
| CHEMBL5079103 | — | EC50 | = | 11300.0 | nM | 4.95 |
| CHEMBL5092714 | — | EC50 | = | 11600.0 | nM | 4.94 |
| CHEMBL5091563 | — | EC50 | = | 13200.0 | nM | 4.88 |
| CHEMBL5094184 | — | EC50 | = | 13300.0 | nM | 4.88 |
| CHEMBL5082938 | — | EC50 | = | 13300.0 | nM | 4.88 |
| CHEMBL5082372 | — | EC50 | = | 13600.0 | nM | 4.87 |
| CHEMBL5084393 | — | EC50 | = | 13400.0 | nM | 4.87 |
| CHEMBL5090639 | — | EC50 | = | 14200.0 | nM | 4.85 |
| CHEMBL5086021 | — | EC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL5094257 | — | EC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL5089852 | — | EC50 | = | 15100.0 | nM | 4.82 |
| CHEMBL5087185 | — | EC50 | = | 15400.0 | nM | 4.81 |
| CHEMBL5084307 | — | EC50 | = | 17100.0 | nM | 4.77 |
| CHEMBL5089224 | — | EC50 | = | 17600.0 | nM | 4.75 |