Assay Detail
Binding
CHEMBL5058892
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cell based cAMP Assays (pA2)
2
Total Activities
2
Compounds Tested
1
Activity Types
3
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Data for DCP probe JNJ-39758979
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 2 | 7.90 | 7.90 |
Assay Parameters
| Parameter | Type | Value | Units | Text |
|---|---|---|---|---|
| Additional information | Additional information | - | — | pA2 indicates the conc. of antagonist when double the agonist is required to have the same effect on the receptor as when no antagonist is present |
| Assay publication | Assay publication | - | — | PMID: 14722321 |
| Target protein type | Target protein type | - | — | SK-N-MC cells expressing human H4 receptor |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3236549 | JNJ-39758979 | 2.0 | 1 | 7.90 |
| CHEMBL3236584 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3236549 | JNJ-39758979 | Kd | = | 12.59 | nM | 7.90 |
| CHEMBL3236584 | — | Kd | > | 100000.0 | nM | - |