Assay Detail

CHEMBL5069388

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Binding

Reverse ITC (compound as receptor). Domain start/stop: G62-S699

ChEMBL ↗

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Target

SRSF protein kinase 2 (CHEMBL5668) ↗

Open DB target context

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Primary target SRSF protein kinase 2

CHEMBL5668

Anchored from Assay target.

Protein identity SRSF protein kinase 2

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Homo sapiens
Category	ITC assay
Confidence	9 — Direct single protein target
Curated By	Autocuration

Target

SRSF protein kinase 2 (CHEMBL5668) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

ITC assay results for EUbOPEN Chemical Probe Library

EUbOPEN
(2022)
· DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
Kd	1	6.84	6.84

Assay Parameters

Parameter	Type	Value	Units	Text
Protein Sequences	Protein Sequences	-	—	MHHHHHHSSGVDLGTENLYFQSMGSDDEEQEDPADYCKGGYHPVKIGDLFNGRYHVIRKLGWGHFSTVWLCWDMQGKRFVAMKVVKSAQHYTETALDEIKLLKCVRESDPSDPNKDMVVQLIDDFKISGMNGIHVCMVFEVLGHHLLKWIIKSNYQGLPVRCVKSIIRQVLQGLDYLHSKCKIIHTDIKPENILMCVDDAYVRRMAAEATEWQKAGAPPPSGSAVSTAPAADLLVNPLDPRNADKIRVKIADLGNACWVHKHFTEDIQTRQYRSIEVLIGAGYSTPADIWSTACMAFELATGDYLFEPHSGEDYSRDEDHIAHIIELLGSIPRHFALSGKYSREFFNRRGELRHITKLKPWSLFDVLVEKYGWPHEDAAQFTDFLIPMLEMVPEKRASAGECLRHPWLNS
Refseq Start/Stop	Refseq Start/Stop	-	—	G62-S699

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL5085558	—	—	1	6.84

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL5085558	—	Kd	=	145.0	nM	6.84