Assay Detail

CHEMBL5096491

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Functional

Antiviral activity against SARS-CoV assessed as reduction in virus-induced cytopathic effect

ChEMBL ↗

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Target

SARS-CoV (CHEMBL4303836) ↗

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Primary target SARS-CoV

CHEMBL4303836

Anchored from Assay target.

Protein identity SARS-CoV

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Severe acute respiratory syndrome-related coronavirus
Confidence	1 — Organism
Curated By	Autocuration

Target

SARS-CoV (CHEMBL4303836) ↗

Type	ORGANISM
Organism	Severe acute respiratory syndrome-related coronavirus

Publication

Natural Products with Potential to Treat RNA Virus Pathogens Including SARS-CoV-2.

Christy MP, Uekusa Y, Gerwick L, Gerwick WH.
J Nat Prod (2021) 84 : 161 -182
PubMed 33352046 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
EC50	1	7.80	7.80

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL400092	LYCORINE	—	1	7.80

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL400092	LYCORINE	EC50	=	15.7	nM	7.80