Assay Detail

CHEMBL5096595

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Binding

Inhibition of CDK1 (unknown origin) expressed in baculovirus-infected Sf9 insect cells

ChEMBL ↗

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Target

Cyclin-dependent kinase 1 (CHEMBL308) ↗

Open DB target context

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Cyclin-dependent kinase 1 (CHEMBL308) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Cyclin-dependent kinase 1

CHEMBL308

Anchored from Assay target.

Protein identity Cyclin-dependent kinase 1

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Homo sapiens
Cell Type	Sf9
Confidence	9 — Direct single protein target
Curated By	Autocuration

Target

Cyclin-dependent kinase 1 (CHEMBL308) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

Development and Therapeutic Potential of NUAKs Inhibitors.

Faisal M, Kim JH, Yoo KH, Roh EJ, Hong SS, Lee SH.
J Med Chem (2021) 64 : 2 -25
PubMed 33356242 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	8.30	8.30

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL4442620	RONICICLIB	2.0	1	8.30

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL4442620	RONICICLIB	IC50	=	5.0	nM	8.30