Assay Detail
Binding
CHEMBL5097376
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PSMA derived from human LNCaP cell lysate assessed as inhibition of NAAG hydrolysis incubated for 2 hrs in presence of NAAG by Amplex Red assay
26
Total Activities
25
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | LNCaP |
| Subcellular | Lysate |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and Biological Evaluation of PSMA Ligands with Aromatic Residues and Fluorescent Conjugates Based on Them.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 7.10 | 8.52 |
| Ki | 3 | 8.44 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5193353 | — | — | 2 | 9.00 |
| CHEMBL5186540 | — | — | 1 | 8.59 |
| CHEMBL5175556 | — | — | 1 | 7.77 |
| CHEMBL5206903 | — | — | 1 | 7.74 |
| CHEMBL5199943 | — | — | 1 | 7.57 |
| CHEMBL5174173 | — | — | 1 | 7.55 |
| CHEMBL5191246 | — | — | 1 | 7.42 |
| CHEMBL5204105 | — | — | 1 | 7.37 |
| CHEMBL5173940 | — | — | 1 | 7.34 |
| CHEMBL5195613 | — | — | 1 | 7.34 |
| CHEMBL5206132 | — | — | 1 | 7.30 |
| CHEMBL5176891 | — | — | 1 | 7.26 |
| CHEMBL5209061 | — | — | 1 | 7.21 |
| CHEMBL5206082 | — | — | 1 | 7.20 |
| CHEMBL47009 | — | — | 1 | 7.10 |
| CHEMBL5181465 | — | — | 1 | 7.10 |
| CHEMBL5182882 | — | — | 1 | 7.05 |
| CHEMBL5209008 | — | — | 1 | 6.97 |
| CHEMBL5194398 | — | — | 1 | 6.97 |
| CHEMBL5200623 | — | — | 1 | 6.76 |
| CHEMBL5184603 | — | — | 1 | 6.65 |
| CHEMBL5171260 | — | — | 1 | 6.53 |
| CHEMBL5202302 | — | — | 1 | 6.50 |
| CHEMBL458202 | — | — | 1 | 6.26 |
| CHEMBL5191610 | — | — | 1 | 5.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5193353 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL5186540 | — | Ki | = | 2.6 | nM | 8.59 |
| CHEMBL5193353 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL5175556 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL5206903 | — | Ki | = | 18.1 | nM | 7.74 |
| CHEMBL5199943 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL5174173 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL5191246 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL5204105 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL5195613 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL5173940 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL5206132 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL5176891 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL5209061 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL5206082 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL5181465 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL47009 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL5182882 | — | IC50 | = | 89.0 | nM | 7.05 |
| CHEMBL5209008 | — | IC50 | = | 107.0 | nM | 6.97 |
| CHEMBL5194398 | — | IC50 | = | 108.0 | nM | 6.97 |
| CHEMBL5200623 | — | IC50 | = | 175.0 | nM | 6.76 |
| CHEMBL5184603 | — | IC50 | = | 226.0 | nM | 6.65 |
| CHEMBL5171260 | — | IC50 | = | 294.0 | nM | 6.53 |
| CHEMBL5202302 | — | IC50 | = | 319.0 | nM | 6.50 |
| CHEMBL458202 | — | IC50 | = | 547.0 | nM | 6.26 |
| CHEMBL5191610 | — | IC50 | = | 3158.0 | nM | 5.50 |