Assay Detail
Functional
CHEMBL5097480
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against SARS CoV-2 (01/human/Jan2020/Thailand) infected in human Calu-3 cells for 2 hrs assessed as inhibition of viral replication measured after 48 hrs post infection by IFA assay
5
Total Activities
4
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
| Cell Type | Calu-3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
SARS-CoV-2 (CHEMBL4303835) ↗| Type | ORGANISM |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
Publication
Anti-SARS-CoV-2 Activity of <i>Andrographis paniculata</i> Extract and Its Major Component Andrographolide in Human Lung Epithelial Cells and Cytotoxicity Evaluation in Major Organ Cell Representatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.40 | 7.37 |
| Activity | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4065616 | REMDESIVIR | 4.0 | 1 | 7.37 |
| CHEMBL1448 | NICLOSAMIDE | 4.0 | 1 | 6.05 |
| CHEMBL186141 | ANDROGRAPHOLIDE | 3.0 | 2 | 5.78 |
| CHEMBL1535 | HYDROXYCHLOROQUINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4065616 | REMDESIVIR | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL1448 | NICLOSAMIDE | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL186141 | ANDROGRAPHOLIDE | IC50 | = | 1680.0 | nM | 5.78 |
| CHEMBL1535 | HYDROXYCHLOROQUINE | IC50 | > | 50000.0 | nM | - |
| CHEMBL186141 | ANDROGRAPHOLIDE | Activity | - | — | - |