Assay Detail

CHEMBL5097481

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional

Antiviral activity against SARS CoV-2 (01/human/Jan2020/Thailand) infected in human Calu-3 cells for 2 hrs assessed as inhibition of viral replication measured after 48 hrs post infection by plague assay

ChEMBL ↗

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Target

SARS-CoV-2 (CHEMBL4303835) ↗

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SARS-CoV-2 (CHEMBL4303835) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target SARS-CoV-2

CHEMBL4303835

Anchored from Assay target.

Protein identity SARS-CoV-2

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Severe acute respiratory syndrome coronavirus 2
Cell Type	Calu-3
Confidence	1 — Organism
Curated By	Autocuration

Target

SARS-CoV-2 (CHEMBL4303835) ↗

Type	ORGANISM
Organism	Severe acute respiratory syndrome coronavirus 2

Publication

Anti-SARS-CoV-2 Activity of <i>Andrographis paniculata</i> Extract and Its Major Component Andrographolide in Human Lung Epithelial Cells and Cytotoxicity Evaluation in Major Organ Cell Representatives.

Sa-Ngiamsuntorn K, Suksatu A, Pewkliang Y, Thongsri P, Kanjanasirirat P, Manopwisedjaroen S, Charoensutthivarakul S, Wongtrakoongate P, Pitiporn S, Chaopreecha J, Kongsomros S, Jearawuttanakul K, Wannalo W, Khemawoot P, Chutipongtanate S, Borwornpinyo S, Thitithanyanont A, Hongeng S.
J Nat Prod (2021) 84 : 1261 -1270
PubMed 33844528 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	2	7.27	7.47

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL186141	ANDROGRAPHOLIDE	3.0	1	7.47
CHEMBL4065616	REMDESIVIR	4.0	1	7.07

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL186141	ANDROGRAPHOLIDE	IC50	=	34.0	nM	7.47
CHEMBL4065616	REMDESIVIR	IC50	=	86.0	nM	7.07