Assay Detail
Binding
CHEMBL5097761
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant aromatase expressed in baculovirus insect cell using 7-methoxy-trifluoromethyl coumarin (MFC) as substrate preincubated for 10 mins followed by substrate addition and measured for 30 mins by fluorescence based assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Isoxazole derivatives as anticancer agent: A review on synthetic strategies, mechanism of action and SAR studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.80 | 8.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5195433 | — | — | 1 | 8.64 |
| CHEMBL1444 | LETROZOLE | 4.0 | 1 | 8.55 |
| CHEMBL185 | FLUOROURACIL | 4.0 | 1 | 6.20 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5195433 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL1444 | LETROZOLE | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL185 | FLUOROURACIL | IC50 | = | 630.0 | nM | 6.20 |