Assay Detail
Toxicity
CHEMBL5097886
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Cytotoxicity against human MRC5 cells
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Toxicity |
| Organism | Homo sapiens |
| Cell Type | MRC5 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structure activity relationship in β-carboline derived anti-malarial agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 4.73 | 5.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1774689 | — | — | 1 | 5.00 |
| CHEMBL1774692 | — | — | 1 | 4.80 |
| CHEMBL1774693 | — | — | 1 | 4.75 |
| CHEMBL1774691 | — | — | 1 | 4.66 |
| CHEMBL5207239 | — | — | 1 | 4.46 |
| CHEMBL5198214 | — | — | 1 | - |
| CHEMBL5204238 | — | — | 1 | - |
| CHEMBL5196122 | — | — | 1 | - |
| CHEMBL1774690 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1774689 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL1774692 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL1774693 | — | IC50 | = | 17800.0 | nM | 4.75 |
| CHEMBL1774691 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL5207239 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL5198214 | — | IC50 | > | 64000.0 | nM | - |
| CHEMBL5204238 | — | IC50 | > | 64000.0 | nM | - |
| CHEMBL5196122 | — | IC50 | > | 64000.0 | nM | - |
| CHEMBL1774690 | — | IC50 | > | 64000.0 | nM | - |