Assay Detail
Toxicity
CHEMBL5097928
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of hERG potassium channel assessed as maximum inhibition rate at -80 mV holding potential incubated for 120 seconds by whole cell-automated voltage clamp analysis assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Toxicity |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Voltage-gated inwardly rectifying potassium channel KCNH2 (CHEMBL240) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design, Synthesis, and Biological Evaluation of Novel Pyrimido[4,5-<i>b</i>]indole Derivatives Against Gram-Negative Multidrug-Resistant Pathogens.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 5.34 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1200788 | CISAPRIDE MONOHYDRATE | 4.0 | 1 | 7.40 |
| CHEMBL5208405 | — | — | 1 | 4.91 |
| CHEMBL5189137 | — | — | 1 | 4.74 |
| CHEMBL5179034 | — | — | 1 | 4.29 |
| CHEMBL5173810 | — | — | 1 | - |
| CHEMBL5198082 | — | — | 1 | - |
| CHEMBL5195776 | — | — | 1 | - |
| CHEMBL5175419 | — | — | 1 | - |
| CHEMBL5187851 | — | — | 1 | - |
| CHEMBL5180811 | — | — | 1 | - |
| CHEMBL5173672 | — | — | 1 | - |
| CHEMBL5172595 | — | — | 1 | - |
| CHEMBL5180991 | — | — | 1 | - |
| CHEMBL5209407 | — | — | 1 | - |
| CHEMBL5190841 | — | — | 1 | - |
| CHEMBL5183179 | — | — | 1 | - |
| CHEMBL5186271 | — | — | 1 | - |
| CHEMBL5181038 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1200788 | CISAPRIDE MONOHYDRATE | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL5208405 | — | IC50 | = | 12300.0 | nM | 4.91 |
| CHEMBL5189137 | — | IC50 | = | 18400.0 | nM | 4.74 |
| CHEMBL5179034 | — | IC50 | = | 51500.0 | nM | 4.29 |
| CHEMBL5173810 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL5198082 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL5195776 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL5175419 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL5187851 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL5180811 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL5173672 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL5172595 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL5180991 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL5209407 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL5190841 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL5183179 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL5186271 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL5181038 | — | IC50 | > | 40000.0 | nM | - |