Assay Detail
Binding
CHEMBL5098261
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to ALK (unknown origin) using TK as substrate incubated for 1 hr in presence of ATP by HTRF analysis
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Development of Alectinib-Based PROTACs as Novel Potent Degraders of Anaplastic Lymphoma Kinase (ALK).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.68 | 6.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4859551 | — | — | 1 | 6.54 |
| CHEMBL3747525 | — | — | 1 | 6.50 |
| CHEMBL1738797 | ALECTINIB | 4.0 | 1 | 5.99 |
| CHEMBL4875115 | — | — | 1 | 4.87 |
| CHEMBL5188519 | — | — | 1 | 4.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4859551 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL3747525 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL1738797 | ALECTINIB | IC50 | = | 1030.0 | nM | 5.99 |
| CHEMBL4875115 | — | IC50 | = | 13630.0 | nM | 4.87 |
| CHEMBL5188519 | — | IC50 | = | 30630.0 | nM | 4.51 |