Assay Detail
Functional
CHEMBL5098262
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Antiproliferative activity against ALK-positive human NCI-H3122 cells assessed as inhibition of cell proliferation measured after 72 hrs by MTT assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H3122 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Development of Alectinib-Based PROTACs as Novel Potent Degraders of Anaplastic Lymphoma Kinase (ALK).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 6.96 | 7.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3747525 | — | — | 1 | 7.42 |
| CHEMBL4859551 | — | — | 1 | 7.40 |
| CHEMBL1738797 | ALECTINIB | 4.0 | 1 | 7.35 |
| CHEMBL4875115 | — | — | 1 | 7.21 |
| CHEMBL5207601 | — | — | 1 | 7.11 |
| CHEMBL4875202 | — | — | 1 | 7.04 |
| CHEMBL5171663 | — | — | 1 | 7.02 |
| CHEMBL4865374 | — | — | 1 | 6.97 |
| CHEMBL5173908 | — | — | 1 | 6.94 |
| CHEMBL5179368 | — | — | 1 | 6.93 |
| CHEMBL5176906 | — | — | 1 | 6.92 |
| CHEMBL5189754 | — | — | 1 | 6.92 |
| CHEMBL5174385 | — | — | 1 | 6.73 |
| CHEMBL4854383 | — | — | 1 | 6.57 |
| CHEMBL5188519 | — | — | 1 | 6.57 |
| CHEMBL5193329 | — | — | 1 | 6.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3747525 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL4859551 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL1738797 | ALECTINIB | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL4875115 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL5207601 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL4875202 | — | IC50 | = | 92.0 | nM | 7.04 |
| CHEMBL5171663 | — | IC50 | = | 96.0 | nM | 7.02 |
| CHEMBL4865374 | — | IC50 | = | 107.0 | nM | 6.97 |
| CHEMBL5173908 | — | IC50 | = | 116.0 | nM | 6.94 |
| CHEMBL5179368 | — | IC50 | = | 118.0 | nM | 6.93 |
| CHEMBL5176906 | — | IC50 | = | 121.0 | nM | 6.92 |
| CHEMBL5189754 | — | IC50 | = | 121.0 | nM | 6.92 |
| CHEMBL5174385 | — | IC50 | = | 186.0 | nM | 6.73 |
| CHEMBL4854383 | — | IC50 | = | 269.0 | nM | 6.57 |
| CHEMBL5188519 | — | IC50 | = | 272.0 | nM | 6.57 |
| CHEMBL5193329 | — | IC50 | = | 612.0 | nM | 6.21 |