Assay Detail
Functional
CHEMBL5098263
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Antiproliferative activity against ALK-positive human KARPAS-299 cells assessed as inhibition of cell proliferation measured after 72 hrs by MTT assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | KARPAS-299 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Development of Alectinib-Based PROTACs as Novel Potent Degraders of Anaplastic Lymphoma Kinase (ALK).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 6.97 | 7.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4875115 | — | — | 1 | 7.38 |
| CHEMBL3747525 | — | — | 1 | 7.34 |
| CHEMBL1738797 | ALECTINIB | 4.0 | 1 | 7.33 |
| CHEMBL4859551 | — | — | 1 | 7.30 |
| CHEMBL4875202 | — | — | 1 | 7.18 |
| CHEMBL5207601 | — | — | 1 | 7.01 |
| CHEMBL5174385 | — | — | 1 | 7.00 |
| CHEMBL5176906 | — | — | 1 | 6.97 |
| CHEMBL4865374 | — | — | 1 | 6.97 |
| CHEMBL5189754 | — | — | 1 | 6.96 |
| CHEMBL5173908 | — | — | 1 | 6.94 |
| CHEMBL5171663 | — | — | 1 | 6.92 |
| CHEMBL5179368 | — | — | 1 | 6.92 |
| CHEMBL4854383 | — | — | 1 | 6.61 |
| CHEMBL5188519 | — | — | 1 | 6.56 |
| CHEMBL5193329 | — | — | 1 | 6.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4875115 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL3747525 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL1738797 | ALECTINIB | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL4859551 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL4875202 | — | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL5207601 | — | IC50 | = | 97.0 | nM | 7.01 |
| CHEMBL5174385 | — | IC50 | = | 101.0 | nM | 7.00 |
| CHEMBL5176906 | — | IC50 | = | 106.0 | nM | 6.97 |
| CHEMBL4865374 | — | IC50 | = | 107.0 | nM | 6.97 |
| CHEMBL5189754 | — | IC50 | = | 111.0 | nM | 6.96 |
| CHEMBL5173908 | — | IC50 | = | 114.0 | nM | 6.94 |
| CHEMBL5171663 | — | IC50 | = | 119.0 | nM | 6.92 |
| CHEMBL5179368 | — | IC50 | = | 119.0 | nM | 6.92 |
| CHEMBL4854383 | — | IC50 | = | 245.0 | nM | 6.61 |
| CHEMBL5188519 | — | IC50 | = | 275.0 | nM | 6.56 |
| CHEMBL5193329 | — | IC50 | = | 640.0 | nM | 6.19 |