Assay Detail
Binding
CHEMBL5098498
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of West Nile Virus NS2B (residues 1393 to 1440 )/NS3pro (residues 1476 to 1687) protease expressed in Escherichia coli BL21 (DE3) using e Pyr- RTKR-AMC as substrate preincubated for 30 mins followed by substrate addition and incubated for 90 mins by fluorescence spectrophotometry assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | West Nile virus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
A short survey of dengue protease inhibitor development in the past 6 years (2015-2020) with an emphasis on similarities between DENV and SARS-CoV-2 proteases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 6.98 | 6.98 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL569561 | — | — | 1 | 6.98 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL569561 | — | IC50 | = | 105.0 | nM | 6.98 |