Assay Detail
Binding
CHEMBL5098674
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of CDK9 (unknown origin) using FITC-X-GSRTPMY-NH2 as substrate preincubated for 10 mins followed by substrate addition and measured after 90 mins in the presence of 5 mM ATP by plate reader analysis
37
Total Activities
37
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of a Series of 7-Azaindoles as Potent and Highly Selective CDK9 Inhibitors for Transient Target Engagement.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 37 | 7.03 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5170524 | — | — | 1 | 8.40 |
| CHEMBL5192311 | — | — | 1 | 8.40 |
| CHEMBL5179773 | — | — | 1 | 8.40 |
| CHEMBL3663760 | — | — | 1 | 8.22 |
| CHEMBL5207871 | — | — | 1 | 8.22 |
| CHEMBL5195947 | — | — | 1 | 8.22 |
| CHEMBL5204473 | — | — | 1 | 8.10 |
| CHEMBL5197170 | — | — | 1 | 8.10 |
| CHEMBL5177440 | — | — | 1 | 8.00 |
| CHEMBL3663770 | — | — | 1 | 8.00 |
| CHEMBL5198372 | — | — | 1 | 7.96 |
| CHEMBL5207146 | — | — | 1 | 7.96 |
| CHEMBL5192022 | — | — | 1 | 7.85 |
| CHEMBL5170195 | — | — | 1 | 7.80 |
| CHEMBL5181511 | — | — | 1 | 7.41 |
| CHEMBL5199352 | — | — | 1 | 7.24 |
| CHEMBL5169733 | — | — | 1 | 7.16 |
| CHEMBL5173492 | — | — | 1 | 7.08 |
| CHEMBL5209369 | — | — | 1 | 7.00 |
| CHEMBL5171361 | — | — | 1 | 6.89 |
| CHEMBL5200778 | — | — | 1 | 6.80 |
| CHEMBL5203694 | — | — | 1 | 6.58 |
| CHEMBL5176464 | — | — | 1 | 6.48 |
| CHEMBL5187219 | — | — | 1 | 6.40 |
| CHEMBL5207813 | — | — | 1 | 6.00 |
| CHEMBL5173041 | — | — | 1 | 6.00 |
| CHEMBL5192909 | — | — | 1 | 5.92 |
| CHEMBL5188442 | — | — | 1 | 5.64 |
| CHEMBL5204939 | — | — | 1 | 5.40 |
| CHEMBL5198594 | — | — | 1 | 5.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5170524 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL5179773 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL5192311 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL3663760 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL5207871 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL5195947 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL5204473 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL5197170 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL5177440 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL3663770 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL5198372 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL5207146 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL5192022 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL5170195 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL5181511 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL5199352 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL5169733 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL5173492 | — | IC50 | = | 84.0 | nM | 7.08 |
| CHEMBL5209369 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL5171361 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL5200778 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL5203694 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL5176464 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL5187219 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL5207813 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL5173041 | — | IC50 | = | 990.0 | nM | 6.00 |
| CHEMBL5192909 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL5188442 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL5204939 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL5198594 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL5192139 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL5201044 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL5175957 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL5181709 | — | IC50 | < | 3.0 | nM | - |
| CHEMBL5180640 | — | IC50 | < | 3.0 | nM | - |
| CHEMBL5198038 | — | IC50 | < | 3.0 | nM | - |
| CHEMBL5191725 | — | IC50 | < | 3.0 | nM | - |