Assay Detail
Binding
CHEMBL5098683
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of CDK1 (unknown origin) using 5FAM-RRRFRPASPLRGPPK-COOH as substrate preincubated for 10 mins followed by substrate addition and measured after 90 mins in the presence of 5 mM ATP by plate reader analysis
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of a Series of 7-Azaindoles as Potent and Highly Selective CDK9 Inhibitors for Transient Target Engagement.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.03 | 5.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5170524 | — | — | 1 | 5.16 |
| CHEMBL5197170 | — | — | 1 | 5.15 |
| CHEMBL3663760 | — | — | 1 | 5.09 |
| CHEMBL5207871 | — | — | 1 | 4.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5170524 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL5197170 | — | IC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL3663760 | — | IC50 | = | 8100.0 | nM | 5.09 |
| CHEMBL5207871 | — | IC50 | = | 19000.0 | nM | 4.72 |