Assay Detail
Binding
CHEMBL5098686
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of CDK12 (unknown origin) using FITC-X-GSRTPMY-NH2 as substrate preincubated for 10 mins followed by substrate addition and measured after 90 mins in the presence of 5 mM ATP by plate reader analysis
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of a Series of 7-Azaindoles as Potent and Highly Selective CDK9 Inhibitors for Transient Target Engagement.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.54 | 5.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5198038 | — | — | 1 | 5.70 |
| CHEMBL5207871 | — | — | 1 | 5.68 |
| CHEMBL5197170 | — | — | 1 | 5.55 |
| CHEMBL5170524 | — | — | 1 | 5.23 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5198038 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL5207871 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL5197170 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL5170524 | — | IC50 | = | 5900.0 | nM | 5.23 |